Pharmaceutical-Grade N-Methyl-2-Pyrrolidone (NMp) Solvent

N-Methyl-2-pyrrolidone (NMp), also known as Pharmacol, is a pharmaceutical-grade solvent with a wide range of applications in the medical and life sciences industries. NMp is a polar aprotic compound that is miscible with water and exhibits advantageous physical properties, including a high boiling point and low freezing point.

As a pharmaceutical solvent, NMp is valued for its ability to act as an effective drug solubilizer and penetration enhancer, both in human and animal applications. NMp's high solvency, ease of handling, and strong chemical/thermal stability make it a versatile choice for various formulations and drug delivery systems.

Despite its utility, NMp is a colorless liquid with a mild, fishy odor that can potentially irritate the eyes, skin, nose, and throat upon exposure. Additionally, overexposure may affect the central nervous system, causing symptoms similar to alcohol intoxication. proper precautions must be taken when handling pharmaceutical-grade NMp.

Overall, the unique solvent properties of NMp, combined with its pharmaceutical-grade purity, make it a valuable tool in the development and manufacture of advanced drug products and medical technologies.

Pharmaceutical Applications of High-Purity N-Methyl-2-Pyrrolidone (NMp) Solvent

N-methyl-2-pyrrolidone (NMp) is a polar aprotic solvent that is miscible with water and other organic solvents. It is used as a drug solubilizer and penetration enhancer in humans and animals. NMp has a favorable toxicity profile and is more efficient than other solvents for improving the solubility of poorly soluble drugs. For example, one study found that NMp was a more efficient solubilizer than ethanol and propylene glycol for 13 poorly soluble drugs, with solubility enhancement of up to 800-fold in 20% v/v NMp.

NMp is also known as Pharmacol. It has been used with many medicines, including human and veterinary products. Some studies have shown that NMp has therapeutic activities for treating atherosclerosis, including:

  • Increasing Klf2 expression: NMp increases Klf2 expression in vivo.
  • Attunement of inflammation genes: NMp attenuates expression of inflammation genes in the aorta.
  • Increasing atheroprotection: NMp treatment increases atheroprotection in HFD-fed ApoE −/− mice.

NMp can be absorbed into the body by inhalation, through the skin, and by ingestion. Exposure to NMp can cause:

  • Rapid, irregular respiration
  • Shortness of breath
  • Decreased pain reflex
  • Slight bloody nasal secretion
  • Headaches
  • Redness and pain
  • A burning sensation in the throat and chest
  • Acute solvent syndrome

NMp is also used as a solvent in the electrode coating of battery manufacturing. It is highly effective for dissolving polyvinylidene fluoride (PVDF), which is the most common material used in the binding of anodes and cathodes in the production of Lithium (Li) batteries.

People May Ask

Which Pharmaceutical Solvent Is Most Popular?

Depending on the needs of the product, various liquids such as ethanol, glycerin, propylene glycol, isopropyl alcohol, and water may also be used as a solvent for medicinal solutions.

What Is The Rate of NMP Solvent Evaporation?

This study demonstrates that the evaporation rate of NMP solvent acquired in the coating will change from 1.18 10-3 to 2.88 10-3 g min-1 cm-2 during the first evaporation stage of the manufacture of lithium battery coatings when the inlet wind speed varies at 2 12 m s-1.

How Do I Pick A Reliable Solvent?

A good crystallization solvent should be non-toxic, affordable, and unreactive. As it is desirable if the solvent rapidly evaporates from the solid once recovered, it is also crucial that the solvent have a relatively low boiling point (b.p. commonly 100oC).

What Purposes Do Solvents Serve in The Production of Pharmaceuticals?

In the pharmaceutical sector, organic solvents are frequently employed as reaction media, in the separation and purification of synthesis products, as well as for cleaning equipment.

What Sort of Medicinal Solvent Comes to Mind?

Ethanol, isopropyl alcohol, glycerin, and propylene glycol are the most popular alcohols used as solvents. Again, some of these are beneficial for external uses, but due to toxicity issues, they might only be beneficial for interior applications in very little levels, if at all.

What Kind of Solvent Is Most Frequently Used to Create Pharmaceutical Formulations?

A. For all uses, water is the most popular and ideal solvent-vehicle for liquid medication formulations and preparations.

What Is N Methyl 2 Pyrrolidone's Vapor Pressure?

The saturation vapor concentration is only about 450 ppm at ambient temperature due to NMP's low vapor pressure (0.342 mm Hg at 25°C).

What Does A Chemical Compound's Thermal Stability Mean?

The tability of a molecule or any chemical under the influence of an extremely high temperature is referred to as thermal tability. The molecule would be less likely to easily break apart or decompose at higher temperatures if it had a higher thermal stability.

What Prerequisites Must Be Met for Thermal Stability?

The requirement for thermal stability • Because thermal runaway can even burn and destroy the transmission, it is essential to prevent it. The pace at which heat is released at the collector connection must not exceed the rate at which the heat can be dissipated in order to prevent thermal runaway.

What Exactly Is A TM Thermal Stability Method?

tandard Thermogravimetry's Tet Method for Thermal Stability. 1.1 This technique measures the thermal stability of a material by determining the temperature at which it begins to break down or react, as well as the magnitude of the change, using thermogravimetry.

Pharmaceutical Grade N-Methyl-2-Pyrrolidone Solvent Products

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