N-Methyl-2-Pyrrolidone (NMp): A Versatile Pharmaceutical-Grade Solvent with Potential Health Risks

1-Methyl-2-pyrrolidone (NMp) is a colorless, water-miscible liquid with a mild, fishy odor. It's also known as pharmasolve and is used as a pharmaceutical solvent and penetration enhancer. NMp is also used in chemical processing, paint thinners, and lithium-ion micro-batteries.

NMp is a high-production volume chemical that's often used as a substitute for chlorinated solvents. It's chemically stable, has a low vapor pressure, and is miscible in water.

NMp has low acute toxicity, but it's teratogenic. It can be absorbed into the body by inhalation, through the skin, and by ingestion. Exposure to NMp can cause:

  • Rapid, irregular respiration
  • Shortness of breath
  • Decreased pain reflex
  • Slight bloody nasal secretion
  • Headaches
  • Redness and pain on skin
  • A burning sensation in the throat and chest
  • Acute solvent syndrome

The European Union has added NMp to its restricted substance list.

N-Methyl-2-Pyrrolidone (NMp): Mechanisms, Applications, And Potential Health Risks

N-Methyl-2-pyrrolidone (NMp) is a pharmaceutical solvent that can reduce inflammation by activating Krüppel-like factor 2. It's also known as pharmasolve.

NMp is a colorless liquid with a mild, fishy odor. It's a strong solubilizing agent that's used in many industries, including pharmaceuticals. It's often used as a substitute for chlorinated solvents.

NMp is absorbed into the body through inhalation, skin exposure, and ingestion. Exposure can cause:

  • Rapid, irregular respiration
  • Shortness of breath
  • Decreased pain reflex
  • Slight bloody nasal secretion
  • Headaches
  • Redness and pain on the skin
  • A burning sensation in the throat and chest
  • Acute solvent syndrome

NMp is also used in:

Chemical processing, paint thinners, Electronics, Automotive and coatings, Chemicals, and Optical.

People May Ask

Which Four Stages Make up FDA Approval?

Information RegardingFirst Step: Research and Development.Preclinical research is the second step.Step 3: Research for Clinical Use.Step 4: FDA Drug Evaluation.Step 5: FDA Drug Safety Monitoring After Market Launch.Jan. 4, 2018

What Is Meant by A Pharma Grade?

a medication, biologic, or reagent that has been given FDA approval for use in people or animals or for which British Pharmacopeia (BP) or the United States Pharmacopeia-National Formulary (USP-NF) has set a chemical purity standard.

How Can You Tell If A Medicine Is of Pharmaceutical Quality?

However, in brief, pharmaceutical grade refers to any drug or component of a drug that has received approval from the United States Food and Drug Administration (FDA) or the United States Pharmacopeia (USP). This contains both active and inactive components, such as water, as well as packaging components.

What Is The Pharmacy's Most Practical Solvent?

LIKE ETHYL ALCOHOL, ETHANOL, AND C2H5OH, ALCOHOL USP: 1- Alcohol is the most practical solvent, second only to water. 2. It works well as a solvent for many organic compounds, both natural and manmade. 3. It disintegrates significant plant components such resins, volatile oils, alkaloids, glycosides, and neutral principles.

N Methyl 2 Pyrrolidone Excipient: What Is It?

NMP is a teratogen (a chemical that can cause birth defects after exposure during pregnancy) in laboratory animals and is utilized as an excipient (component of a medicine other than the active substance) in several veterinary treatments.

What Is 1-Methyl-2-Pyrrolidinone's Functional Group?

A member of the class of pyrrolidine-2-ones, or pyrrolidin-2-ones in which the hydrogen linked to the nitrogen is replaced by a methyl group, is N-methylpyrrolidin-2-one. As a polar aprotic solvent, it serves a purpose. It belongs to the pyrrolidin-2-ones family, is a lactam, and is a N-alkylpyrrolidine.

What Distinguishes FDA-Approved Products from Those That Are Not?

"FDA approved" indicates that the product's "benefits outweigh the known risks for the intended use," according to the regulatory body. To obtain approval, manufacturers must submit a premarket approval (PMA) application and the outcomes of clinical trials.

What Are NMP's Risks?

Depending on the animal test, you should treat NMP as a possible threat to human reproduction. An much exposure to NMP irritates the throat, eyes, nose, and skin. It can also have an effect on the brain or the central nervous system, causing symptoms of intoxication similar to those caused by consuming alcohol.

What Exactly Is FDA Pharmaceutical Grade?

Pharmaceutical-grade substance: Any drug, biologic, reagent, or other substance produced in accordance with Good Manufacturing Practices (GMP) and approved, conditionally approved, or listed by the Food and Drug Administration (FDA), or for which a chemical purity standard has been developed or established by a...

What Purpose Does Pyrrolidone Serve?

Both as a polar solvent and a metabolite, 2-pyrrolidone serves a purpose. Pharmaceutical formulations contain the chemical 2-pyrrolidone. 2-Pyrrolidone is a solvent with excellent properties that is frequently utilized. Its boiling point is high for 2-pyrrolidone.

Pharmaceutical Grade 1-Methyl-2-Pyrrolidone Products

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All B vitamins are included in the 100 tablets of the Bronson Super B Vitamin B Complex Sustained Slow Release (Vitamin B1, B2, B3, B6, B9 - Folic Acid, B12).

(60 Count, 600mg Servings) Alpha GPC Choline Brain Supplement for Acetylcholine Double Wood's Advanced Memory Formula, Focus and Brain Support Supplement, and Focus Supplement are all made in the USA.

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