NMP（N-甲基吡咯烷酮）主要通过丁二醇（BDO）合成路线生产。首先，从1,4-丁二醇（BDO）合成γ-丁内酯（GBL），再与甲胺反应生成NMP。这一方法目前是最可靠和成熟的工业生产路线。由于该工艺具有悠久的工业应用历史，经过高度优化，能够实现大规模生产，同时具备高效率和低成本的特点。

Key Features of the BDO Route:

Uses copper-based catalysts enhanced with additives like zinc, aluminum, chromium, and manganese to boost reactivity and selectivity.

High conversion rates: 98% for BDO, 95% selectivity, and >90% yield.

No dependency on external hydrogen sources (by-product hydrogen is generated).

Flexible production scale: Can be adapted for small or large operations using readily available 1,4-butanediol as the raw material.

Economic viability hinges on the cost and availability of 1,4-butanediol.

γ-Butyrolactone (GBL) Production Process

1. Feedstock Preparation:

1,4-butanediol is pumped into a heater, heated with thermal oil, and mixed with recycled hydrogen in a static mixer.

The mixture is further heated to fully vaporize the BDO before entering a dehydrogenation reactor.

2. Reaction & Separation:

The dehydrogenation reaction occurs under controlled temperature and pressure.

Post-reaction, products and hydrogen exchange heat in a product-hydrogen heat exchanger, then cool via circulating water.

The cooled mixture enters a gas-liquid separator:

Liquid product (crude GBL) flows to storage.

Hydrogen is partially recycled (after compression and reheating) or purified for other uses.

3. Purification:

Crude GBL is pumped to an azeotropic column to remove light impurities.

Further refined in a product distillation column to obtain high-purity GBL, which is then stored.

NMP Synthesis Process

1. Reaction Setup:

Pure GBL and a 40% methylamine aqueous solution are metered into a steam preheater, mixed in a static mixer, and fed into an amination reactor.

2. High-Pressure Reaction:

The reaction occurs at 230–260°C and 7.0–8.0 MPa pressure.

Products are cooled and depressurized to atmospheric pressure in a constant-pressure tank, then stored as crude NMP.

3. Purification Steps:

Deamination: Crude NMP is pumped to a deamination column to recover ~30% methylamine solution (recycled for reuse).

Dehydration: Residual liquid from deamination goes to a dehydration column; water from the top is sent to wastewater treatment.

4. Distillation:

The dehydrated product enters a middle fraction column for preliminary separation.

Final refinement in a product distillation column yields pure NMP, which is stored and packaged.

5. Waste Handling: Bottom residues from distillation are collected and sent to licensed recyclers or incinerated.

This process ensures efficient, scalable production of NMP with minimal waste and high recovery of by-products like hydrogen and methylamine.